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The continued use of the endometrial biopsy for the diagnosis of luteal phase defects (LPDs) and in the general evaluation of the infertile couple is based largely on tradition, the absence of a clearly superior diagnostic modality, the absence of studies that have either validated or repudiated its efficacy with certainty, its ability to assess the endometrial response irrespective of endogenous progesterone levels, its ability to monitor the endometrial response to hormonal therapy in fertility treatments, and, finally, its ability to exclude other intrinsic endometrial anomalies that may be detrimental to the implantation of the conceptus, such as chronic endometritis or neoplasia.

From the *Department of Pathology and †Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut.

The engagement of TLR 2/6 with its ligand in the uterine horn during embryo transfer severely affected the rate of embryonic implantation (45.00 ± 6.49 vs 16.69 ± 5.01%, P ABSTRACT: The current understanding of hormonal regulation of matrix metalloproteinase-26 (MMP-26) in the primate endometrium is incomplete.

The goal of this work was to clarify estrogen and progesterone regulation of MMP-26 in the endometrium of ovariectomized, hormone-treated rhesus macaques.

Traditionally, the first day of menstruation is taken as day 1 of an idealised 28-day cycle while ovulation is conventionally timed at day 14.

Variation in the cycle is usually due to differences in the proliferative phase as collapse of the secretory phase into menstruation if fertilisation does not take place is relatively more predictable than the proliferative phase.

Failure in implantation is highly recurrent and impossible to diagnose.

Inflammation and infections in the female reproductive tract are common causes of infertility, embryo loss and preterm-labor.

The nuclei rather than centrally-located are pseudostratified, though they tend to be found in the basal half.

The interval phase occurs over a short period of 24-48 hours.

Meanwhile, continued use of the criteria of Noyes et al for endometrial dating is recommended until more precise modalities for assessing the adequacy of endometrial maturation are available. AB - The continued use of the endometrial biopsy for the diagnosis of luteal phase defects (LPDs) and in the general evaluation of the infertile couple is based largely on tradition, the absence of a clearly superior diagnostic modality, the absence of studies that have either validated or repudiated its efficacy with certainty, its ability to assess the endometrial response irrespective of endogenous progesterone levels, its ability to monitor the endometrial response to hormonal therapy in fertility treatments, and, finally, its ability to exclude other intrinsic endometrial anomalies that may be detrimental to the implantation of the conceptus, such as chronic endometritis or neoplasia.

Meanwhile, continued use of the criteria of Noyes et al for endometrial dating is recommended until more precise modalities for assessing the adequacy of endometrial maturation are available. KW - Endometrial biopsy KW - Endometrial dating KW - Infertility KW - Luteal phase defect UR -